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G Ital Cardiol 2004;5(10 Suppl. 6):63S-67S

New positive inotropic agents in the treatment of left ventricular dysfunction

Leonardo De Luca, Paola Proietti, Gian Luca Palombaro, Alessandro Battagliese, Annalisa Celotto, Chiara Bucciarelli-Ducci, Francesco Fedele

Three major classes of inotropic agents have been clinically evaluated in patients with left ventricular dysfunction: a) agents that increase the intracellular concentration of cyclic adenosine monophosphate by stimulating the beta-adrenergic receptor or inhibiting phosphodiesterase; b) drugs that increase the intracellular sodium concentration; c) the new calcium-sensitizing drugs.
This review will focus on the newest drug for each of the above-mentioned classes of inotropic agents. Moreover, we present a new protocol which provides the use of levosimendan in patients with post-ischemic left ventricular dysfunction.

Il Pensiero Scientifico Editore
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